“The road leading to the vaccine is always uphill”. Let’s arm ourselves and go? The tragic case Syncytial Pneumonia case
After uttering these wise words, inexplicably the distinguished Burioni deleted the tweet.
And why on earth, we ask ourselves. Perhaps because he realized on his own, (or maybe he asked for help from home), or after a fair flurry of peppery responses to the tweet, he assessed that to convince those he amiably called "mice" to get vaccinated, it was better to use less alarming, less direct, more subtly and psychologically blackmailing methods. He asked, "Do it for the grandparents, for a Christmas of hugs, for the good of all, because otherwise you are a murderer, murderer and rat and you won't come to my house for dinner, and not even at my friends' house, we will take you away. 'medical assistance, work, you will die only without friends in the indifference of the righteous ”.
In short, we will never know from him, because in this case scripta volant.
Fortunately, thanks to the fastest screenshots on the web we were able to keep the stamp of the disturbing tweet, which does not give us so much the opportunity to talk about the utterances of the well-known luminary, as to deepen what happened during the vaccination trials against the respiratory syncytial virus .
“In the 1950s and 1960s there was a wide spread of the so-called“ Respiratory Syncytial Virus ”, a virus that caused an upper respiratory tract infection, which often caused severe pneumonia, with tens of thousands of children dead. The success against polio led to a push for a vaccine against this type of pneumonia. In 1967, infants and young children immunized with a formalin-inactivated respiratory syncytial virus (RSV) vaccine experienced an advanced form of RSV disease characterized by high fever, bronchopneumonia, and wheezing when infected with the wild-type virus in the community. Hospitalizations were frequent and two immunized infants died from wild-type RSV infection. Advanced disease was initially characterized as 'peribronchiolar monocytic infiltration with an excess of eosinophils'. Decades of research have defined enhanced RSV disease (ERD) as the result of immunization with raw antigens in the cytoplasm, resulting in a non-protective antibody response and triggering of the CD4 + T helper in the absence of cytotoxic T lymphocytes. This response to vaccination led to a pathogenic Th2 memory response with deposition of eosinophils and immune complexes in the lungs after RSV infection. In recent years, the field of RSV has undergone significant changes. Numerous candidate vaccines with new designs and formulations are approaching clinical trials, challenging our previous understanding of favorable parameters for ERD. This review provides a succinct analysis of these parameters and explores the criteria for assessing the risk of ERD in new vaccine candidates.
https://journals.asm.org/doi/10.1128/cvi.00609-15?permanently=true
A respiratory syncytial virus vaccine (RSV vaccine) is a vaccine that prevents respiratory syncytial virus infection.
“Attempts to develop a vaccine against RSV began in the 1960s with an inactivated vaccine failure developed by exposing the RSV virus to formalin (formalin-inactivated RSV (FI-RSV)). [1] Unfortunately, this vaccine induced a phenomenon that has become known as "Vaccine-Associated Enhanced Respiratory Disease" (VAERD), in which children who had not previously been exposed to RSV and subsequently vaccinated developed severe form of RSV disease when exposed. the virus itself, including fever, wheezing, and bronchopneumonia. [1] About eighty percent of these infants (versus 5% of virus-exposed controls) were hospitalized and two infants died from a fatal pulmonary inflammatory response during the first natural RSV infection after vaccination of naive infants to RSV. [1] This disaster hindered vaccine development for many years to come. [1]
A 1998 paper reported that research towards vaccine development had progressed significantly over the past 10 years. [2] The desired vaccine would prevent RSV lower respiratory tract infection in at-risk populations and, if possible, be useful in other lower-risk populations. [2] Twenty years later, a 2019 paper similarly stated that research into vaccine development had progressed significantly over the past 10 years. [3] The same study predicted that a vaccine would be available within 10 years. [3]
The current types of vaccines being researched are particle-based vaccines, attenuated vaccines, protein subunit vaccines or vector-based vaccines ". [4] Encyclopedia site: it.wikiqube.net
These are the facts. So the research continues, uphill, and the experiments in the name of science rightly advance incessantly, albeit with some hitch. Moreover, even the road to hell is paved with good intentions (cit).
It is now up to us to decide whether to arm ourselves with boots and ice axes and proceed heroically towards the summit or “but also not”. After all, free will is still in vogue in Italy. So you can calmly choose whether to leave of your own free will or, already rumored, if forced to do so. For those who reach the summit healthy, the Greenpassino d'Oro is free.
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The article "The road to the vaccine is always uphill". Let's arm ourselves and go? The tragic case of Syncitial Pneumonia case comes from ScenariEconomici.it .
This is a machine translation of a post published on Scenari Economici at the URL https://scenarieconomici.it/la-strada-che-conduce-al-vaccino-e-sempre-in-salita-armiamoci-e-partite-il-tragico-caso-polmonite-sinciziale-caso/ on Thu, 28 Oct 2021 14:19:17 +0000.