The incredible mystery of the birth of Covid: when did he flee China?
The mystery about the true date of origin of the covid deepens as, for scientific purposes, the tests on biological samples acquired before December 2019 expand.
Recently, a team of Italian researchers discovered one of the strongest evidence of pre-pandemic SARS-CoV-2 infection outside of China in samples taken from an autopsied patient who died on December 09, 2019.This sample is the third positive for SARS-CoV-2 RNA in Italy and the fourth positive for SARS-CoV-2 RNA in the world, taken before the onset date of the first officially recognized SARS-CoV-2 case in China, a shrimp seller working in the Huanan seafood market, with a symptom onset date as of December 10, 2019.
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The team of researchers performed a retrospective investigation of 169 deceased patients, who were autopsied between October 1, 2019 and March 27, 2020 and with well-preserved blood samples, to check for the presence of SARS-CoV-2 RNA. by RT-PCR and the presence of SARS-CoV-2 N- and S RBD- targeting antibodies by LFIA and ELISA assay. Five patients tested positive for at least one of the tests. Four patients tested positive for SARS-CoV-2 anti-N IgM or IgG antibodies by LFIA, while one patient, who died on 09/12/2019 and underwent autopsy on 16/12/2019, tested positive for both antibodies SARS-CoV-2 anti-RBD by ELISA and SARS-CoV-2 RNA in blood and lung samples by RT-PCR. The results indicate that this patient was infected with SARS-CoV-2 at the time of death, one day before the first symptoms were manifested by the first case of SARS-CoV-2 infection at the Huanan seafood market in China. .
Another study examined 39 oropharyngeal swab samples collected in the period September 2019-February 2020 during measles and rubella surveillance, from patients suspected of measles but ultimately negative for measles. RT-PCR testing was conducted using primers targeting the protein coding region of SARS-CoV-2, which revealed that one of 39 oropharyngeal swab samples was positive. The sample was collected by a 4-year-old boy who lived near Milan and had no previous travel abroad.
The first sample currently known to be positive for the presence of the SARS-CoV-2 virus (RNA and nucleocapsid protein antigen) worldwide was an autopsy skin sample taken on 10 November 2019 from a female patient in Milan with a manifestation of plaque dermatosis in the arm. SARS-CoV-2 RNA was detected by in situ fluorescent hybridization targeting the protein S coding sequence from eccrine gland cells of the skin sample, while an immunohistochemical staining assay identified the presence of nucleocapsid protein antigens from the skin sample. SARS-CoV-2 within the same cells as the skin sample.
These are not the only cases of Covid-19 outside China prior to December 10, the official birth date of Covid-19: a study in Brazil that conducted a retrospective analysis of wastewater samples taken in Florianopolis, Santa Catarina , using qRT-PCR, showed that the wastewater samples tested positive for SARS-CoV-2 as of 11/27/2019 and remained consistently positive for all 3 samples taken after this date, with a titer constant of ~ 10 ^ 6 genome copies per liter of the wastewater sample. If the presence in the waste water was such that it could be detected, it means that the virus had been circulating and had been doing so for some time
All these studies are necessary in order to understand the true timing of the spread of Covid-19 and also to understand the uselessness of most of the measures taken in March 2020. The virus was already endemic in Italy then, so the lockdowns did not have great medical utility. Furthermore, it is necessary to study not December or November 2019 in Wuhan, but the previous months, there or anywhere else in the world.
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The article The incredible mystery of the birth of Covid: when did he escape from China? comes from ScenariEconomici.it .
This is a machine translation of a post published on Scenari Economici at the URL https://scenarieconomici.it/lincredibile-mistero-della-nascita-del-covid-quando-e-fuggito-dalla-cina/ on Mon, 15 Aug 2022 19:21:14 +0000.